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Objective:To investigate the value of gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid (Gd-EOB-DTPA)-enhanced MRI in predicting the pathological grade and early recurrence rate of hepatocellular carcinoma.Methods:The imaging data, pathological data, and follow-up data of 90 patients with hepatocellular carcinoma who underwent Gd-EOB-DTPA-enhanced MRI examination and surgical treatment in People's Hospital of Baise from January 2016 to October 2017 were retrospectively analyzed. The correlation between the signal intensity of contrast-enhanced MRI and postoperative pathological grade was analyzed. Kaplan-Meier survival analysis was performed to investigate the effects of the signal characteristics of hepatobiliary lesions on the early recurrence rate of hepatocellular carcinoma.Results:A total of 59 (65.56%) patients showed low-intensity signals and 31 (34.44%) patients showed mixed-intensity signals. High-intensity signal was not found in any patients. The signal intensity of the hepatobiliary phase was significantly correlated with the pathological grade of the tumor ( χ2 = 2.26, P = 0.040) and tumor size ( t = 3.10, P = 0.033). The early recurrence rate of hepatocellular carcinoma was significantly higher in patients exhibiting mixed-intensity signals than that in patients exhibiting low-intensity signals ( χ2 = 2.25, P = 0.041). Conclusion:Gd-EOB-DTPA-enhanced MRI in the hepatobiliary phase with different signal intensities has the potential to predict the pathological grade and early recurrence rate of hepatocellular carcinoma.
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Objective@#To explore the correlation between quantitative parameters of dynamic enhanced magnetic resonance imaging (DCE-MRI) and Dukes stage, lymph node metastasis, tumor differentiation degree and molecular biological indicators [Ki67 and human epidermal growth factor receptor 2 (CerbB-2)] of rectal cancer.@*Methods@#This study was a prospective study. From October 2014 to October 2017, 168 cases of rectal cancer patients were selected as the research objects. DCE-MRI was performed preoperatively to obtain the quantitative parameter values of region of interest (ROI) [apparent diffusion coefficient (ADC)mean, Ktrans, Ve, and Kep] in tumor site. The expression of Ki67 and CerbB-2 were detected by immunohistochemical. Correlations of DCE-MRI quantitative parameter values and rectal cancer Dukes staging, lymph node metastasis, tumor differentiation degree to Ki67 and CerbB-2 expression level were analysised.@*Results@#With the increase of tumor differentiation, ADCmean was increasing, while Ktrans and Ve showed a downward trend, with significant difference (P<0.05). Among them, Ktrans and Ve in the high-differentiation group and the medium-differentiation group were significantly lower than those in the low-differentiation group (P<0.05), while there was no statistical significance between the high-differentiation group and the medium-differentiation group (P>0.05). The ADCmean was statistically significant between different groups (P<0.05), while Kep was not statistically significant (P>0.05). The ADCmean of lymph node metastasis group was significantly lower than that of no lymph node metastasis group (P<0.001), while Ktrans, Ve and Kep were significantly higher than that of no lymph node metastasis group (P<0.001). With the increase of Dukes staging in rectal cancer, ADCmean was decreasing and Ktrans was increasing, with statistically significant difference (P<0.001); among which the ADCmean of Dukes A and B was significantly higher than that of Dukes C and D (P<0.05), and Ktrans was significantly lower than that of Dukes C and D (P<0.05). Ktrans and Kep were increased with the increased expression levels of Ki67 and CerbB-2, and the difference between Ktrans and Kep was statistically significant (P<0.05). The ADCmean decreased with the increase of Ki67 and CerbB-2 expression level, and the difference was statistically significant (P<0.05).@*Conclusions@#DCE-MRI quantitatively participates can reflect the biological behavior of rectal cancer, and can be used to evaluate the prognosis of tumors and guide the clinical selection of more appropriate treatment options.
ABSTRACT
Objective To explore the correlation between quantitative parameters of dynamic enhanced magnetic resonance imaging (DCE-MRI) and Dukes stage,lymph node metastasis,tumor differentiation degree and molecular biological indicators [Ki67 and human epidermal growth factor receptor 2 (CerbB-2)] of rectal cancer.Methods This study was a prospective study.From October 2014 to October 2017,168 cases of rectal cancer patients were selected as the research objects.DCE-MRI was performed preoperatively to obtain the quantitative parameter values of region of interest (ROI) [apparent diffusion coefficient (ADC) Ktrans,Ve,and Kep] in tumor site.The expression of Ki67 and CerbB-2 were detected by immunohistochemical.Correlations of DCE-MRI quantitative parameter values and rectal cancer Dukes staging,lymph node metastasis,tumor differentiation degree to Ki67 and CerbB-2 expression level were analysised.Results With the increase of tumor differentiation,ADCmean was increasing,while Ktrans and Ve showed a downward trend,with significant difference (P ＜ 0.05).Among them,Ktrans and Ve in the high-differentiation group and the medium-differentiation group were significantly lower than those in the low-differentiation group (P ＜ 0.05),while there was no statistical significance between the high-differentiation group and the medium-differentiation group (P ＞ 0.05).The ADC was statistically significant between different groups (P ＜ 0.05),while Kep was not statistically significant (P ＞ 0.05).The ADCmean of lymph node metastasis group was significantly lower than that of no lymph node metastasis group (P ＜0.001),while Ktrans,Ve and Kep were significantly higher than that of no lymph node metastasis group (P ＜0.001).With the increase of Dukes staging in rectal cancer,ADCmean was decreasing and Ktrans was increasing,with statistically significant difference (P ＜0.001);among which the ADCmean of Dukes A and B was significantly higher than that of Dukes C and D (P ＜ 0.05),and Ktrans was significantly lower than that of Dukes C and D (P ＜ 0.05).Ktrans and Kep were increased with the increased expression levels of Ki67 and CerbB-2,and the difference between Ktrans and Kep was statistically significant (P ＜ 0.05).The ADCmean decreased with the increase of Ki67 and CerbB-2 expression level,and the difference was statistically significant (P ＜ 0.05).Conclusions DCE-MRI quantitatively participates can reflect the biological behavior of rectal cancer,and can be used to evaluate the prognosis of tumors and guide the clinical selection of more appropriate treatment options.